Welcome to ProteinArchitect

ProteinArchitect is an open source project that evolved from a collaboration between the Friedrich Miescher Institute for Biomedical Research in Switzerland (Michael Rebhan) and the Upper Austrian University of Applied Sciences, Department of Bioinformatics, in Hagenberg, Austria (Matthias Haimel).

Using one or more protein sequences as input, it runs different types of analysis and combines their results in the form of a compact, information-rich visualization of protein features. Using this output, it is then possible to perform a detailed visual comparison of structural features that include PFAM domains, propensities for secondary structure elements (helix, strand, loop), propensities for intrinsic disorder (structural flexibility), and predictions of transmembrane regions for a number of proteins. Applications include the assessment of the results of homology searches (as many of those features are more conserved than the sequence itself) and the visualization of subgroups in protein collections such as protein families and superfamilies.

Submitting data:

If you have any comments or questions, or if you would like to contribute something to this project, we invite you to use the Tracker at our Project page at SourceForge, where you can also find more details about the scientific and technical approach used in this work.